難治性

善，通常被稱為難治性抑郁癥,難治性抑郁癥具有復發率高、致殘率高和生活質量低等特點，給患者帶來痛苦，給社會和家屬帶來極大的負擔[1]。目前，難治性抑郁癥的病理機制尚不明確。研究發現抑郁癥患者下丘腦-垂體-腎上腺皮質（hypothalamic-pituitary-adrenocortical，HPA）系統存在功能亢進，而下丘腦-垂體-甲狀腺（hypothalamic-pituitary-thyroid–adrenocortical，HPT）系統功能低下，主要表

nner DL難治性抑郁癥; 抗抑郁藥替換; 抗抑郁藥聯合治療; 增效Summary:Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment